I'm a research scientist affiliated with the Nathan Price Group at the Institute for Systems Biology in Seattle, Washington, USA.
My work focuses on integrating multi-omic data sets to enable biological discovery (e.g. doi:10.1093/jamia/ocv077). I build cloud-based computational infrastructure and work with bioinformatic and statistical inference approaches to analyze things like short-read sequence data ("data science").
Lately, I've really been enjoying working to become a better software developer and to adapt an action-biased culture of software engineering (e.g. my work with the Minimal Identifier Pilot Project).
Previously, my doctoral research focused on the computational reconstruction of the metabolic network of the yeast Saccharomyces cerevisiae (e.g. doi:10.1089/ind.2012.0002, doi:10.1186/1752-0509-6-55, doi:10.1093/database/bat059).
As a postdoc in the Price lab, I continued to work on metabolic network reconstruction research, (e.g. doi:10.1016/j.copbio.2014.12.010, doi:10.1371/journal.pcbi.1004530), and expanded my research focus as I began learning more about probabalistic modeling, such as those used for reconstructing gene regulatory networks or evaluating short-read sequence data.
Academic and Professional Background
- Ph.D. Cornell University 2012
- Biological and Environmental Engineering
- M.S. University of Colorado at Boulder 2004
- Civil and Environmental Engineering
- B.S. University of Puget Sound 1999
- Majors: Mathematics, Natural Sciences with an emphasis in Physics
- Postdoctoral Research Fellow - Institute for Systems Biology, Seattle WA
- Graduate Research Assistant - Cornell University, Ithaca, NY
- Environmental Engineer - Shannon & Wilson, Inc., Anchorage, AK
- Post-Bachelors Technical Research Assistant - Los Alamos National Laboratory, Los Alamos, NM
- Systems Administrator - ArsDigita, Cambridge, MA
- Visiting Technical Advisor - Africa University, Mutare, Zimbabwe
Peer Reviewed Publications
Heavner BD, Price ND. 2015. "Comparative Analysis of Yeast Metabolic Network Models Reveals Progress, Opportunities for Metabolic Reconstruction." PLOS Computational Biology. doi:10.1371/journal.pcbi.1004530
Toga AW, Foster I, Kesselman C, Madduri R, Chard K, Deutsch EW, Price ND, Glusman G, Heavner BD, Dinov ID, Ames J, Van Horn J, Kramer R, Hood L. 2015. "Big Biomedical data as the key resource for discovery science." Journal of the American Medical Informatics Association. Ocv077. doi:10.1093/jamia/ocv077
Heavner BD, Price ND. 2015. "Transparency in metabolic network reconstruction enables scalable biological discovery." Current opinion in biotechnology. 34:105-109. doi:10.1016/j.copbio.2014.12.010
Richards MA, Cassen V, Heavner BD, Ajami NE, Hermann A, Simeonidis E, Price ND. 2014. "MediaDB: A Database of Microbial Growth Conditions in Defined Media." PLOS one 2014, no. 9 e103548. doi:10.1371/journal.pone.0103548
Heavner BD, Smallbone K, Price ND, Walker LP. 2013. "Version 6 of the Consensus Yeast Metabolic Network Refines Biochemical Coverage and Improves Model Performance." Database 2013, no. 0 (August 9, 2013): bat059–bat059. doi:10.1093/database/bat059.i
Heavner B.D., Smallbone K., Barker B., Mendes P., Walker L.P. 2012. "Yeast 5 - an expanded reconstruction of the Saccharomyces cerevisiae metabolic network." BMC Systems Biology, 6:55. [doi:10.1186/1752-0509-6-55]
Heavner B.D., Henry S.A., and Walker L.P. 2012. "Evaluating Sphingolipid Biochemistry in the Consensus Reconstruction of Yeast Metabolism." Industrial Biotechnology, 8(2):72-78. [doi:10.1089/ind.2012.0002]